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Publikationen

Originalarbeiten

  1. Mester, Radu, Scripcariu, Dragos, Hutter, Gerhild (1980) NAD kinase from Saccharomyces carlsbergensis. Purification and characterization. Rev. Roum. Biochim. 17, 4, 263-271.

  2. Eckel, Jürgen, van Echten, Gerhild, Reinauer, Hans (1985) Adult cardiac myocytes in culture: Cell characteristics and insulin-receptor interaction. Am. J. Physiol. 249, H212-H221.

  3. van Echten, Gerhild, Eckel, Jürgen, Reinauer, Hans (1986) Down-regulation of insulin receptors in the heart: Studies on primary cultured adult cardiac myocytes. Biochim. Biophys. Acta 886, 468-473.

  4. van Echten, Gerhild, Sandhoff, Konrad (1989) Modulation of ganglioside biosynthesis in primary cultured neurons. J. Neurochem. 52, 207-214.

  5. van Echten, Gerhild, Iber, Heinrich, Stotz, Harald, Takatsuki, Akira, Sandhoff, Konrad (1990) Uncoupling of ganglioside biosynthesis by Brefeldin A. Eur. J. Cell Biol. 51, 135-139.

  6. van Echten, Gerhild, Birk, Rolf, Brenner-Weiß, Gerald, Schmidt, R. Richard, Sandhoff, Konrad (1990) Modulation of sphingolipid biosynthesis in primary cultured neurons by long chain bases. J. Biol. Chem. 265, 9333-9339.

  7. Iber, Heinrich, van Echten, Gerhild, Klein, A. Roger, Sandhoff, Konrad (1990) pH-Dependent changes of ganglioside biosynthesis in neuronal cell culture. Eur. J. Cell Biol. 52, 236-240.

  8. Iber, Heinrich, van Echten, Gerhild, Sandhoff, Konrad (1991) Substrate specificity of 2->3 sialyltransferases in ganglioside biosynthesis of rat liver Golgi. Eur. J. Biochem. 195, 115-120.

  9. Mandon, C. Elisabet, van Echten, Gerhild, Birk, Rolf, Schmidt, R. Richard, Sandhoff, Konrad (1991) Sphingolipid biosynthesis in cultured neurons - Down-regulation of serine palmitoyltransferase by sphingoid bases. Eur. J. Biochem.198, 667-674.

  10. Iber, Heinrich, van Echten, Gerhild, Sandhoff, Konrad (1992) Fractionation of primary cultured neurons: Distribution of sialyltransferases involved in ganglioside biosynthesis. J. Neurochem., 58, 1533-1537.

  11. Mandon, C. Elisabet, Ehses, Ingrid, Rother, Jürgen, van Echten, Gerhild, Sandhoff, Konrad (1992) Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J. Biol. Chem. 267, 11144-11148.

  12. Rother, Jürgen, van Echten, Gerhild, Schwarzmann, Günter, Sandhoff, Konrad (1992) Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells. Biochem. Biophys. Res. Commun. 189, 14-20.

  13. Klima, Horst, Klein, Andreas, van Echten, Gerhild, Schwarzmann, Günter, Suzuki, Kunihiko, Sandhoff, Konrad (1993) Over-expression of a functionally active human GM2-activator protein in Escherichia coli. Biochem. J. 292, 571-576.

  14. Merrill, Alfred, H. Jr., van Echten, Gerhild, Wang, Elaine, Sandhoff, Konrad (1993) Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. J. Biol. Chem. 268, 27299-27306.

  15. Zacharias, Claudia, van Echten-Deckert, Gerhild, Plewe, Michael, Schmidt, R. Richard, Sandhoff, Konrad (1994) A truncated epoxy-glucosylceramide uncouples glycosphingolipid biosynthesis by decreasing lactosylceramide synthase activity. J. Biol. Chem. 269, 13313-13317.

  16. Kolter, Thomas, van Echten-Deckert Gerhild, Sandhoff, Konrad (1994) Synthesis of sphinganine analogues modified in the head group. Tetrahedron 50, 13425-13432.

  17. Zacharias, Claudia, van Echten-Deckert, Gerhild, Wang, Elaine, Merrill, Alfred, H., Jr., and Sandhoff, Konrad (1996) The effect of fumonisin B1 on developing chick embryos: Correlation between de novo sphingolipid biosynthesis and gross morphological changes. Glycoconjugate J. 13, 167-175.

  18. Arni, Stephan, Ilangumaran, Subburaj, van Echten-Deckert, Gerhild, Sandhoff, Konrad, Poincelet, Monique, Briol, Anne, Runager-Brändle, Elisabeth and Hoessli, Daniel, C. (1996) Differential regulation of Src-family protein tyrosine kinases in GPI domains of T lymphocyte plasma membranes. Biochem. Biophys. Res. Commun. 225, 801-807.

  19. Hirschberg, Koret, Zisling, Rivka, van Echten-Deckert, Gerhild, Futermann, Anthony H. (1996) Ganglioside synthesis during the development of neuronal polarity. J. Biol. Chem. 271, 14876-14882.

  20. van Echten-Deckert, Gerhild, Zschoche, Alexandra, Bär, Thomas, Schmidt, R. Richard, Raths, Andrea, Heinemann, Thomas, Sandhoff, Konrad (1997) cis-4-Methylsphingosine decreases sphingolipid biosynthesis by specifically interfering with serine palmitoyltransferase activity in primary cultured neurons. J. Biol. Chem. 272, 15825-15833.

  21. Michel, Christoph, van Echten-Deckert, Gerhild, Rother, Jürgen, Sandhoff, Konrad, Wang, Elaine, Merrill, Alfred, H., Jr. (1997) Characterization of ceramide synthesis: A dihydroceramide desaturase introduces the 4,5-trans-double bond of sphingosine at the level of dihydroceramide. J. Biol. Chem. 272, 22432-22437.

  22. van Echten-Deckert, Gerhild, Klein, Andreas, Linke, Thomas, Heinemann, Thomas, Weisgerber, Judith, Sandhoff, Konrad (1997) Turnover of endogenous ceramide in cultured normal and Farber fibroblasts. J. Lipid Res. 38, 2569-2579.

  23. Michel, Christoph, van Echten-Deckert, Gerhild (1997) Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum. FEBS Lett. 416, 153-155.

  24. van Echten-Deckert, Gerhild, Giannis, Athanassios, Schwarz, Andreas, Futerman, Anthony, H., Sandhoff, Konrad (1998) 1-Methylthiodihydroceramide, a novel analog of dihydroceramide, stimulates sphinganine degradation resulting in a decreased de novo sphingolipid biosynthesis. J. Biol. Chem. 273, 1184-1191.

  25. van Echten-Deckert, Gerhild, Schick, Andreas, Heinemann, Thomas, Schnieders, Barbara (1998) Phosphorylated cis-4-methylsphingosine mimics the mitogenic effect of sphingosine-1-phosphate in Swiss 3T3 fibroblasts. J. Biol. Chem. 273, 23585-23589.

  26. Ilangumaran, Subburaj, Arni, Stephan, van Echten-Deckert, Gerhild, Borisch, Bettina, Hoessli, Daniel, C. (1999) Microdomain-dependent regulation of Lck and Fyn protein-tyrosine kinases in T lymphocyte plasma membranes. Mol. Biol. Cell 10, 891-905.

  27. Herget, Thomas, Esdar, Christina, Oehrlein , Silke A., Heinrich, Michael, Schütze, Stefan, Maelicke, Alfred, van Echten-Deckert, Gerhild (2000) Production of ceramides causes apoptosis during early neural differentiation in vitro. J. Biol. Chem. 275, 30344-30354.

  28. Sadeghlar, Farsaneh, Sandhoff, Konrad, van Echten-Deckert, Gerhild (2000) Cell type specific localization of sphingomyelin biosynthesis. FEBS. Lett. 478, 9-12.

  29. van Echten-Deckert, Gerhild, Nätzger, Sven (2001) The role of sphingolipids in cell signaling. Studies with synthetic analogues. Proc. Internatl. Convention of the Pharm. Soc. Korea 2, 102-108.

  30. Nätzker, Sven, Heinemann, Thomas, Figueroa-Perez1, Santiago, Schnieders, Barbara, Schmidt, R. Richard, Sandhoff, Konrad, van Echten-Deckert, Gerhild (2002) cis-4-Methylsphingosine-phosphate induces apoptosis in neuroblastoma cells by opposite effects on p38 and ERK MAPKs. Biol. Chem. 383, 1885-1894.

  31. Elsen, Lutz, Betz, Raymund, Schwarzmann, Günter, Sandhoff, Konrad, van Echten-Deckert, Gerhild (2002) Identification of ceramide binding proteins in neuronal cells. Neurochem. Res. 27, 717-727.

  32. Pelled, Dori, Riebeling, Christian, van Echten-Deckert, Gerhild, Sandhoff, Konrad, Futerman, H. Anthony (2003) Reduced rates of axonal and dendritic growth in embryonic hippocampal neurons cultured from a mouse model of Sandhoff disease. Neuropathol. and Appld. Neurobiol. 29, 341-349.

  33. Betz, Raymund, Sandhoff , Konrad, Fischer, Klaus-Dieter, van Echten-Deckert, Gerhild (2003) Detection and identification of Vav1 protein in primary cultured murine cerebellar neurons and in neuroblastoma cells (SH-SY5Y and Neuro-2a). Neurosci. Lett. 13, 37-40.

  34. Semac, Isabelle, Palomba, Carmen, Kulangara, Karina, Klages Natacha, van Echten-Deckert, Gerhild, Borisch, Bettina, Hoessli, Daniel C. (2003) Anti-CD20 therapeutic antibody rituximab modifies the functional organization of rafts/microdomains of B lymphoma cells. Cancer Res. 63, 534-540.

  35. Dragusin, Mihaela, Gurgui, Cristian, Schwarzmann, Günter, Hoernschemeyer, Joerg and van Echten-Deckert, Gerhild. (2003) Metabolism of the unnatural anticancer lipid safingol (L-threo-dihydrosphingosine) in cultured cells. J. Lipid Res. 44, 1772-1779.

  36. Buccoliero, Rosaria, Bodennec Jaques, van Echten-Deckert, Gerhild, Sandhoff, Konrad, Futerman, Anthony H. (2004) Phospholipid synthesis is specifically decreased in neuronal tissues in a mouse model of Sandhoff disease. J. Neurochem. 90, 80-88

  37. Triola, Gemma, Fabrias, Gemma, Dragusin, Mihaela, Niederhausen, Lars, Broere, Roland, Llebaria, Amadeu, van Echten-Deckert, Gerhild. (2004) Specificity of the dihydroceramide desaturase inhibitor GT11 in primary cultured cerebellar neurons. Mol. Pharmacol. 66, 1671-1678

  38. Allende, Maria L., Sasaki, Teiji, Kawai, Hiromichi, Olivera, Ana, Mi Yide, van Echten-Deckert, Gerhild, Hajdu Richard, Rosenbach Mark, Keohane Carol Ann, Mandala, Suzanne, Spiegel, Sarah, Proia, Richard L. (2004) Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J. Biol. Chem.  279, 52487-52492

  39. Nätzker, Sven, Hagen, Nadine, van Echten-Deckert, Gerhild. (2006) Activation of p38 mitogen-activated protein kinase and partial reactivation of the cell cycle by cis-4-methylsphingosine direct postmitotic neurons towards apoptosis. Genes to Cells 11, 269-279.

  40. Dragusin, Mihaela, Wehner, Sven, Kelly, Samuel, Wang, Elaine, Merrill, Alfred H. Jr.,  Kalff, Jörg C., van Echten-Deckert, Gerhild. (2006) Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications in postoperative ileus. The FASEB J 20, 1930-1932

  41. van Echten-Deckert, Gerhild, Saathoff H Manuela, Kirfel, Gregor, Herzog, Volker. (2007) Specific distribution of barrier-relevant ceramides in the developing epidermis and the periderm/subperiderm cell-layers during chicken embryogenesis. Eur. J. Cell Biol. 86, 675-682

  42. Kralj, A., Gurgui, M., König, M.G., van Echten-Deckert, G. (2007) Trichothecenes induce accumulation of glucosylceramide in neural cells by interfering with lactosylceramide synthase activity. Toxicol. Appl. Pharmacol. 225, 113-122. Online available via the following DOI link: http://dx.doi.org/10.1016/j.taap.2007.08.005

  43. Kralj, A., Kehraus, S., Krick, A., van Echten-Deckert, G., König, M. G. (2007)  Two New Depsipeptides from the Marine Fungus Spicellum roseum. Planta medica 73, 366-371

  44. Broere, R, Gurgui, M, van Echten-Deckert, G. (2007) Identification of target genes of sphingosine-1-phosphate using DualChip technology in intestinal smooth muscle cells. Supplement to CHIM OGGI Vol 25 nr 5, 28-30

  45. Tauzin, Sebastien, Ding, Heidrun, Khatib, Karim, Ahmad, Ishtiag, Burdevet, Dimitri, van Echten-Deckert, Gerhild, Lindquist, A. Jonathan, Schraven, Burkhart, Nasir-du-Din, Borisch, Bettina, Hoessli, C. Daniel. (2008) Oncogenic association of the Cbp/PAG adaptor protein with the Lyn tyrosine kinase in human B-NHL rafts. Blood 111(4),2310-20

  46. Sell, H., Eckardt, K., Taube, A., Tews, D., Gurgui, M., van Echten-Deckert, G., Eckel, J. (2008) Skeletal muscle insulin resistance induced by adipocyte-conditioned medium: underlying mechanisms and reversibility. Am. J. Physiol. Endocrinol. Metab.294(6), E1070-E1077

  47. Hagen, N., Van Veldhoven P.P., Proia R.L., Park, H., Merill, H.A.Jr., van Echten-Deckert, G. (2009) Subcellular origin of sphingosine-1-phosphate is essential for its toxic effect in lyase-deficient neurons. J. Biol. Chem. 284:11346-53

  48. Wei, L., Wedeking, A., Büttner, R., Kalff, C.J., Tolba, H.R., van Echten-Deckert, G. (2009) A natural tetrahydropyrimidine protects small bowel from cold ischemia and subsequent  arm in vitro reperfusion injury. Pathobiol. 76: 212-220 (www.karger.com/pat)

  49. Gurgui, M., Broere, R., Kalff, J.C., van Echten-Deckert, G. (2010) Dual action of sphingosine 1-phosphate in eliciting proinflammatory responses in primary cultured rat intestinal smooth muscle cells. Cell Signal. 22(11):1727-33. 

  50. Teta, R., Gurgui, M., Helfrich, E.J.N., Künne, S., van Echten-Deckert, G., Mangon, A., Piel, J. (2010) Genome Mining Reveals trans-AT Polyketide Synthase-Directed Antibiotic Biosynthesis in the Bacterial Phylum Bacteroidetes. ChemBioChem. 11: 2506 - 2512

  51. ter Braak, M., Claas, R.F., Hegen, B., Labocha, S., Ferreirós, N., Pfeilschifter, J., Huwiler, A., van Echten-Deckert, G., Meyer zu Heringdorf D. (2011) Cis-4-Methylsphingosine is a Sphingosine-1-phosphate Receptor Modulator. Biochem. Pharmacol. 81: 617-625

  52. Hagen, N., Hans, M., Hartmann, D., Swandulla, D., van Echten-Deckert, G. (2011) Sphingosine-1-phosphate links sphingolipid metabolism to neurodegeneration via a calpain-mediated mechanism. Cell Death Differ. 18: 1356-1365
    http://www.nature.com/cdd/journal/vaop/ncurrent/full/cdd20117a.html.

  53. Hagen-Euteneuer N., Lütjohann D., Park H., Merrill AHJr, van Echten-Deckert G. (2012) S1P-lyase-deficiency increases sphingolipid formation via recycling at the expense of de novo biosynthesis in neurons. J. Biol. Chem. 287:9128-36
    http://www.jbc.org/content/early/2012/01/30/jbc.M111.302380.full.pdf+html

  54. Taube, A.,  Lambernd, S., van Echten-Deckert, G., Eckard, K., Eckel, J. (2012) Adipokines promote lipotoxicity in human skeletal muscle cells. Arch. Physiol. Biochem.  12:92-101
    http://informahealthcare.com/doi/pdf/10.3109/13813455.2012.688751.html

  55. Pech,T., Ohsawa, I., Praktiknjo, M., Overhaus, M., Wehner, S., Abu-Elmagd, K., van Echten-Deckert, G., Kalff, C.J., Schaefer, N. (2013) A natural tetrahydropyrimidine (ectoine) ameliorates ischemia reperfusion injury after intestinal transplantation in rats. Pathobiol. 80:102-110.

  56. A. Nakabachi, R. Ueoka, K. Oshima, R. Teta, A. Mangoni, M. Gurgui, NJ. Olaham, G. van Echten-Deckert, K. Okamura, Y. Hongoh, S. Miyagishima, M. Hattori, J. Piel, T. Fukatsu. (2013) Defensive Bacteriome Symbiont with a Drastically Reduced Genome. Curr. Biol. 23: 1478-84.
    Curr Biol. 2013 Aug 5;23(15):1478-84. doi: 10.1016/j.cub.2013.06.027. Epub 2013 Jul 11.

 

Übersichtsarbeiten (reviews)

  1. Sandhoff, Konrad, van Echten, Gerhild, Schröder, Maria, Schnabel, Doris, Suzuki, Kunihiko (1992) Metabolism of glycolipids. The role of glycolipid-binding proteins in the function and pathobiochemistry of lysosomes. Biochem. Soc. Trans. 20, 695-699.

  2. van Echten, Gerhild, Sandhoff, Konrad (1993) Ganglioside Metabolism. Enzymology, topology and regulation. J. Biol. Chem. 268, 5341-5344.

  3. Sandhoff, Konrad, Kolter, Thomas, van Echten-Deckert, Gerhild (1998) Sphingolipid metabolism: Sphingoid analogs, sphingolipid activator proteins and the pathology of the cell. Annals New York Acad. Sci. 845, 139-151.

  4. Schulze, Heike, Michel, Christoph, van Echten-Deckert, Gerhild (2000) Dihydroceramide desaturase. In: Methods in Enzymology (Y.A. Hannun, A.H. Merrill, eds.) Academic Press San Diego, Vol. 311, p. 22-30.

  5. van Echten-Deckert, Gerhild (2000) Steuerung der Sphingolipid-Biosynthese. Signalfunktion von Sphingolipid-Metaboliten. Biospektrum 3, 194-195.

  6. van Echten-Deckert, Gerhild (2000) Sphingolipid extraction, and analysis by thin-layer chromatography. In: Methods in Enzymology (Y.A. Hannun, A.H. Merrill, eds.) Academic Press San Diego, Vol. 312, p. 64-79.

  7. van Echten-Deckert, Gerhild, Herget, Thomas. (2006) Sphingolipid metabolism in neural cells. Biochim. Biophys. Acta 1758, 1978-1994.

  8.  Wedeking, A., van Echten-Deckert, G. (2007) Glycosphingolipid structure and function in membranes. Curr. Org. Chem. 11, 579-589.

  9. van Echten-Deckert, G., Gurgui, M. (2008) Golgi Localization of Glycosyltransferases Involved in Ganglioside Biosynthesis, Current Drug Targets 9, 282-291.

  10. van Echten-Deckert, G., Walter, J. (2012) Sphingolipids: Critical players in Alzheimer's disease,
    Prog Lipid Res 51, 378-393.
    dx.doi.org/10.1016/j.plipres.2012.07.001

  11. Walter, Jochen, van Echten-Deckert, Gerhild (2013): Cross-talk of membrane lipids and Alzheimer-related proteins. Mol. Neurodegen. 8:34-45.
    doi:10.1186/1750-1326-8-34

 

Buchbeiträge (Book chapters)

  1. Sandhoff, Konrad, van Echten, Gerhild (1993) Ganglioside metabolism - Topology and regulation. In: Advances in Lipid Research (Bell, R.M., Hannun, Y.A., Merrill, A.H.Jr. eds.) Academic Press, Vol. 26, p. 119-142.

  2. Sandhoff, Konrad, van Echten, Gerhild (1994) Ganglioside metabolism: Enzymology, topology and regulation. In: Progress in Brain Research (L. Svennerholm, A.K. Ashbury, R.A. Reisfeld, K. Sandhoff, K. Suzuki, G. Tettamanti, G. Toffano, eds.), Elsevier Science B.V., Chapter 2, Vol. 101, p. 17-29.

  3. Sandhoff, Konrad, van Echten, Gerhild (1994) Metabolism of gangliosides - Topology, pathobiochemistry and sphingolipid activator proteins. In Current Topics in Membranes (Hoekstra, D. ed.), Academic Press, Chapter 3, Vol. 40, p. 75-91.

  4. Sandhoff, Konrad, van Echten, Gerhild (1994) Topology and regulation of ganglioside metabolism - Function and pathobiochemistry of sphingolipid activator proteins. In: Glyco- and Cell biology - 44. Colloquium Mosbach - (Wieland, F., Reutter, W. eds.), Springer Verlag, 69 –79.

  5. Sandhoff, Konrad, van Echten-Deckert, Gerhild (1995) Glycolipids of cellular surfaces: Topology of metabolism, function and pathobiochemistry of glycolipid binding proteins. In: Trafficking of Intracellular Membranes: From molecular sorting to membrane fusion (Pedroso de Lima, M. C., Düzgünes, N., Hoekstra, D. eds.), Springer Verlag, NATO ASI Series, Vol. H 91, p. 235-246.

  6. Suzuki, Kunihiko, van Echten-Deckert, Gerhild, Klein, Andreas, Sandhoff, Konrad (1995) Glycosphingolipids and sphingolipid activator proteins: Cell biology, biochemistry and molecular genetics. In: Biochemistry of Cell Membranes. A compendium of selected topics (Papa, S., Tager, J.M. eds.), Birkhäuser Verlag, 137-149.

  7. van Echten-Deckert, Gerhild, Sandhoff, Konrad (1999) Organization and topology of sphingolipid metabolism. In: Comprehensive Natural Products Chemistry (B.M. Pinto, ed.) Elsevier Science Amsterdam-Oxford, Vol. 3, p.87-106.

  8. Wedeking, Annika, van Echten-Deckert, Gerhild. (2006) Sphingolipid metabolism and function in nerve tissue. In: Sphingolipids and Cell Function (E. Albi, ed.) Research Signpost, 137-167.